SAN FRANCISCO — For the first time, scientists have proof in human subjects that a derivative of an ingredient in red wine combats some symptoms of aging. Sirtris Pharmaceuticals announced the results here on Monday at the JPMorgan Healthcare Conference. Resveratol, naturally found in red wine, stimulates a gene known as SIRT1, which has been linked with extended lifespans in rodents. The new study is the first time similar effects have been replicated in humans. ‘We believe that this is the first time that a drug candidate has shown efficacy in a disease of aging by targeting the genes that control aging,’ said Christoph Westphal, CEO of Sirtris. Sirtris was co-founded by David Sinclair, a Harvard Medical School researcher, who discovered SIRT1’s role in regulating lifespan. His early work was in yeast, and he later showed that stimulating SIRT1 through a calorie-restricted diet helped animals live longer. Then, Sinclair found resveratol, which stimulates the same gene with results similar to calorie-restriction but without the diet. Resveratrol’s effects in mice touched off a storm of excitement among people, including Sinclair, who began taking the drug in its over-the-counter form hoping to extend their lifespans. Sirtris’ proprietary formulation […]