Large meta-study reveals aspirin bleeding risks outweigh heart benefits

Stephan:  Like many men my age, my physician has had me taking 81mg aspirin for years. Now the issue has become more complex. If you are on this regime I urge you to consult with your doctor; that's what I plan to do. Citation: https://jamanetwork.com/journals/jama/article-abstract/2721162

The study concludes the bleeding risks associated with taking aspirin outweigh any potential cardiovascular benefits in people that are generally healthy Credit: VadimVasenin /Depositphotos

A large meta-study from a team of UK researchers has examined data from over a dozen different clinical trials to conclude that the dangers of daily aspirin use may outweigh any potential benefits for individuals that are generally healthy.

Aspirin is inarguably an amazing drug. It was officially isolated as a compound, and dubbed aspirin, back in 1899 but its natural precursor, often derived from willow trees, has been used medicinally in various cultures for thousands of years. In addition to its common uses, in the second half of the 20th century the drug became known as an effective preventative medicine for heart attacks, and by the late 1980s daily use was regularly recommended by physicians, especially for older patients.

Over recent years the safety of this general recommendation has been questioned by some researchers suggesting aspirin increases a person’s riskof suffering […]

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Gum infection could be linked to Alzheimer’s, study says

Stephan:  More new medical research. Once again, take counsel with your medical advisor.

A gum infection was found to be a potential risk factor of Alzheimer’s disease in a study published Wednesday in the journal Science Advances.

The bacteria Porphyromonas gingivalis, known as Pg, lead to the gum infection chronic periodontitis, causing chronic inflammation and potential tooth loss.
This same bacteria were also found in 51 out of 53 brain autopsies of Alzheimer’s disease patients, according to new research by Dr. Stephen Dominy and Casey Lynch, founders of the pharmaceutical firm Cortexyme. The pharmaceutical company, which is focused on developing therapeutics to alter the course of Alzheimer’s disease, funded the research.
Following on from their findings, the team also tested blocking the bacteria in mice […]

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Newly Discovered Mechanism Helps Our Own Immune Systems Fight Cancer

Stephan:  And some good news in cancer research.

Cancer disease cell, malignant tumor lesions
Credit: 3D illustration/GETTY

An international team of researchers has discovered a new mechanism that will better activate the immune system against cancer.

The mechanism allows immune cells to detect and destroy cancer cells better than before, according to the study published this month in the journal Nature.

The study was led by Prof. Nick Haining, of Harvard Medical School, and co-authored by Prof. Erez Levanon, doctoral student Ilana Buchumansky, of the Mina and Everard Goodman Faculty of Life Sciences at Bar-Ilan University, and an international team.

In the study, researchers focused on a mechanism that routinely serves the cell by marking human virus-like genes in order to avoid identifying them as viruses. Together with the Harvard team, Levanon has discovered that “when inhibiting this mechanism, the immune system can be harnessed to fight cancer cells in a particularly efficient manner, and most effectively in lung cancer and melanoma.”

“We found […]

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FDA’s opioids adviser accuses agency of having ‘direct’ link to crisis

Stephan:  Once again we have another proof that in the United States we do not have a healthcare system we have an illness profit system manipulated to assure the continued and growing profits of the uber rich who control the system.

Families and friends who have lost loved ones to opioid overdoses leave pill bottles outside the Purdue Pharma headquarters in protest on 17 August 2018. Credit: Jessica Hill/AP

KANSAS CITY, MISSOURI — The Food and Drug Administration is sacrificing American lives by continuing to approve new high-strength opioid painkillers, and manipulating the process in favor of big pharma, according to the chair of the agency’s own opioid advisory committee.

Dr Raeford Brown told the Guardian there is “a war” within the FDA as officials in charge of opioid policy have “failed to learn the lessons” of the epidemic that has killed hundreds of thousands of people over the past 20 years and continues to claim about 150 lives a day.

Brown accused the agency of putting the interests of narcotics manufacturers ahead of public health, most recently by approving a “terrible drug”, Dsuvia, in a process he alleged was manipulated.

“They should stop considering any new opioid evaluation,” said Brown. “For every day and every week and every month that the FDA don’t […]

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Nuclear Energy Plants Are Closing, Hurt by High Prices and Bad PR

Stephan:  Here is some good news. Few people understand that civilian nuclear was a cold war project in order to provide enough support to GE and Westinghouse to make keeping staffs of nuclear competent people employed so they could make naval nuclear reactors. Nuclear has never made any sense as a civilian power source because the waste products must be maintained in expensive special facilities for centuries or longer, much longer.

Nuclear power plant
Credit: Jeanne Menjoulet / Flickr

Once hailed as a key part of the energy future of the United Kingdom and several other countries, the high-tech atomic industry is now heading in the opposite direction, towards nuclear sunset.

It took another body blow last week when plans to build four new reactors on two sites in the U.K. were abandoned as too costly by the Japanese company Hitachi. This was even though it had already sunk £2.14 billion (300 billion yen) in the scheme.

Following the decision in November by another Japanese giant, Toshiba, to abandon an equally ambitious scheme to build three reactors at Moorside in the north-west of England, the future of the industry in the U.K. looks bleak.

The latest withdrawal means the end of the Japanese dream of keeping its nuclear industry alive by exporting its technology overseas. With the domestic market killed by the Fukushima disaster in 2011, overseas sales were to have been its salvation.

U.K. Policy Needed

It also leaves the British plan to lead an international nuclear renaissance by building […]

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