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Adults with hypertension who do not have diabetes have a lower risk for developing the disease when taking their blood pressure medication at bedtime compared with adults who take the medication upon awakening, according to research in Diabetologia.

In a randomized, prospective, open-label, blinded endpoint trial, the researchers also found that adults who took antihypertensive medications at bedtime significantly decreased their ambulatory BP.

“Ingesting hypertension medications at bedtime, instead of upon awakening in the morning, improves asleep BP control and markedly reduces the risk of diabetes,” Ramón C. Hermida, PhD, director of the bioengineering and chronobiology laboratories at the University of Vigo, Spain, told Endocrine Today.

Hermida and colleagues analyzed data from 2,012 Spanish adults with hypertension but without diabetes (1,036 women; mean age, 53 years; mean BMI, 29 kg/m²; mean duration of hypertension, 6.8 years) who adhere to a routine of daytime activity and nighttime sleep. Participants were randomly assigned to ingest all BP-lowering medications upon awakening (n = 1,029) or to take the complete daily dose of one […]