Mad honey disease is among the rarest afflictions in the world, but it appears to be on the increase. Only 58 cases have been reported worldwide, but eight people were treated in 2005 alone. The trend towards eating more natural products may be driving a rise in cases of the disease, whose symptoms can include convulsions, low blood pressure, fainting and temporary heart problems, according to a new report. ‘Mad honey disease has the potential to cause death if untreated,’ say the researchers. ‘Because of the increasing preference for natural products, intoxication induced by consumption of honey will increase in the future.’ Just a spoonful of the wrong honey can cause problems, according to researchers, who report their findings this week in the American Journal of Emergency Medicine. Mad honey poisoning is most prevalent in honey from the Black Sea region of Turkey. Compounds called grayanotoxins, found in the nectar of rhododendrons, mountain laurels and azaleas, are thought to be responsible for the disease. Though harmless to bees, they are psychoactive and poisonous to humans. Affected honey is said to have a very bitter taste.